Quinoline-3-carboxamides modulate primary T cell-dependent B cell responses but do not inhibit functional immunity.

Summary, in English

The effect of a quinoline-3-carboxamide on the T-cell-dependent B-cell response was investigated in C57BL/6 mice after NP-CGG immunization. The primary serum response to the hapten was slightly inhibited by treatment with a quinoline-3-carboxamide. This inhibition was paralleled by reduced numbers of germinal center B cells and follicular T cells in the spleen up to 21 days after immunization. Also, both the number of germinal centers formed and their size was reduced by quinoline-3-carboxamide treatment. In contrast to the observation in the primary immune response there was no inhibitory effect on the secondary immune response. These data could help to explain how quinoline-3-carboxamides can modulate immune function in autoimmune diseases without being immunosuppressive. This article is protected by copyright. All rights reserved.

• Author: Eva Källberg; Fredrik Ivars; Tomas Leanderson
• Department/s: Immunology
• Publishing year: 2014
• Language: English
• Pages: 237-243
• Publication/Series: Scandinavian Journal of Immunology
• Volume: 79
• Issue: 4
• Links: http://www.ncbi.nlm.nih.gov/pubmed/24383944?dopt=Abstract; http://dx.doi.org/10.1111/sji.12152
• Document type: Journal article
• Publisher: Wiley-Blackwell
• Topic: Immunology in the medical area
• Status: Published
• Research group: Immunology
• ISBN/ISSN/Other: ISSN: 1365-3083