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Magnetic CLEAR supports for solid-phase synthesis of peptides and small organic molecules

På svenska

Author

Summary, in English

Paramagnetic versions of the CLEAR supports were prepared by entrapment of magnetite particles during suspension polymerization of allylamine, trimethylolpropane ethoxylate (14/3 EO/OH) triacrylate, and trimethylolpropane trimethacrylate. Swelling studies in a broad range of solvents showed comparable swelling of magnetic beads and regular CLEAR beads. The application of the magnetic beads as the support in solid-phase synthesis of peptides (Leu-enkephalinamide, substance P, acyl carrier protein (65-74) amide, and amyloid beta-protein (34-42) amide) and small organic affinity ligands based on the s-triazine scaffold was demonstrated. Adequate stability of the beads and retention of their magnetic properties were observed throughout the synthesis steps.

Publishing year

2007

Language

English

Pages

129-141

Publication/Series

International Journal of Peptide Research and Therapeutics

Volume

13

Issue

1-2

Document type

Journal article

Publisher

Springer

Topic

  • Pharmacology and Toxicology

Keywords

  • suspension polymerization
  • substance P
  • s-triazine scaffold
  • synthesis
  • solid-phase
  • resin
  • magnetite
  • magnetic support
  • Leu-enkephalin
  • CLEAR
  • acyl carrier protein (65-74)
  • amyloid beta-protein (34-42)

Status

Published

Research group

  • Nanomedicine and Biomaterials

ISBN/ISSN/Other

  • ISSN: 1573-3904