Tissue repair in lung disorders
Author
Summary, in English
Matrix production by fibroblasts in patients who have undergone lung transplantation and in asthmatic subjects involves both the central and the distal parts of the lung. In lung-transplanted patients, the production of proteoglycans in the distal part was found to be double that in the central part. Versican production was particularly elevated compared to controls. The production of proteoglycans was further correlated with proliferation rate. A common feature of fibroblasts in patients after lung transplantation and asthmatic subjects was that these cells proliferated more slowly than in control subjects. Distally-derived fibroblasts from asthmatic subjects produced more veriscan, were immobile, and had many protrusions. The distal parts of the lungs were also rich in collagen.
A better understanding of fibrocyte and fibroblast function will help us to characterise the mechanisms behind idiopathic pulmonary disease, asthma, obliterative bronchiolitis. This knowledge can then be applied to other types of fibrotic disorders.
Publishing year
2009
Language
English
Publication/Series
Lund University Faculty of Medicine Doctoral Dissertation Series
Volume
2009:122
Full text
Document type
Dissertation
Publisher
Lund University: Faculty of Medicine
Topic
- Respiratory Medicine and Allergy
- Cell and Molecular Biology
Status
Published
Research group
- Lung Biology
ISBN/ISSN/Other
- ISSN: 1652-8220
- ISBN: 978-91-86443-11-5
Defence date
11 December 2009
Defence time
09:00
Defence place
Belfragesalen, D15, BMC, Lund
Opponent
- Gunnar Pejler