Der Einfluss von P-Fimbrien auf eine Leukozyturie und den Schwellenwert einer persistierenden Bakteriurie [Effect of P fimbriae on pyuria and bacterial colonization of the human urinary tract]

Summary, in English

This study investigated the role of P fimbriae in colonization of Escherichia coli, host response, and bacterial persistence in humans. Human volunteers were inoculated intravesically with the nonadherent ABU isolate E. coli 83972 and with P fimbriated transformants of the same strain. During the following 24 h all urine samples, and thereafter daily samples, were collected for urine culture, analysis of neutrophil numbers, and cytokine concentrations (IL-6 and IL-8). The P fimbriated transformants showed enhanced bacterial colonization in comparison to E. coli 83972 and lowered the bacterial numbers needed for persistent bacteriuria. The P fimbriated transformants also lowered the bacterial numbers needed for a significant neutrophil and cytokine host response. We conclude that P fimbriae enhance bacterial colonization and trigger the host response in the human urinary tract.

• Author: Björn Wullt; Göran Bergsten; Martin Samuelsson; Catharina Svanborg
• Department/s: Urology; Division of Microbiology, Immunology and Glycobiology - MIG; Clinical Microbiology, Malmö
• Publishing year: 2003
• Language: German
• Pages: 233-237
• Publication/Series: Der Urologe
• Volume: 42
• Issue: 2
• Links: http://dx.doi.org/10.1007/s00120-002-0287-y
• Document type: Journal article
• Publisher: Springer
• Topic: Urology and Nephrology
• Keywords: symptomatische Bakteriurie; E. coli 83972; P-Fimbrien; Harnwegsinfektionen; Wirtsreaktion
• Status: Published
• Research group: Urology; Clinical Microbiology, Malmö
• ISBN/ISSN/Other: ISSN: 0340-2592