Imaging of Intracellular and Extracellular ROS Levels in Atherosclerotic Mouse Aortas Ex Vivo: Effects of Lipid Lowering by Diet or Atorvastatin.

Summary, in English

The first objective was to investigate if intracellular and extracellular levels of reactive oxygen species (ROS) within the mouse aorta increase before or after diet-induced lesion formation. The second objective was to investigate if intracellular and extracellular ROS correlates to cell composition in atherosclerotic lesions. The third objective was to investigate if intracellular and extracellular ROS levels within established atherosclerotic lesions can be reduced by lipid lowering by diet or atorvastatin.

• Author: Matias Ekstrand; Maria Gustafsson Trajkovska; Jeanna Perman-Sundelin; Per Fogelstrand; Martin Adiels; Martin Johansson; Lillemor Mattsson-Hultén; Jan Borén; Max Levin
• Department/s: Clinical pathology, Malmö; BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
• Publishing year: 2015
• Language: English
• Publication/Series: PLoS ONE
• Volume: 10
• Issue: 6
• Full text: - 2 MB; Download statistics
• Links: http://www.ncbi.nlm.nih.gov/pubmed/26098110?dopt=Abstract; http://dx.doi.org/10.1371/journal.pone.0130898
• Document type: Journal article
• Publisher: Public Library of Science (PLoS)
• Topic: Cardiac and Cardiovascular Systems
• Status: Published
• Research group: Clinical pathology, Malmö
• ISBN/ISSN/Other: ISSN: 1932-6203