Serum cystatin C is a better marker for preeclampsia than serum creatinine or serum urate
Author
Summary, in English
Altered renal function is an essential component of the pathophysiological process in preeclampsia. The kidneys play a significant part in the turnover of most low molecular weight substances such as creatinine, urate and cystatin C. The present work was undertaken to investigate if the serum levels of these components are altered in characteristic ways in preeclampsia, and can be used to assist in the diagnosis of this condition. The serum levels were therefore determined in samples from 100 healthy women at term as well as in 45 samples of patients with preeclampsia (diastolic blood pressure >90 mmHg; urinary albumin excretion >300 mgL(-1)). The levels of all three components were significantly higher in samples from preeclamptic patients with the mean+SD being 1.55+/-0.29 vs. 1.05+/-0.19 mg L(-1) for cystatin C, 70+/-23 vs. 56+/-9.7 micromol L(-1) for creatinine, and 413+/-128 vs. 305+/-61 micromol L(-1) for urate. Receiver operating characteristic analysis demonstrated that the serum level of cystatin C had a superior diagnostic accuracy for preeclampsia compared to those of serum urate and creatinine and that the diagnostic accuracy of serum urate was better than that of serum creatinine.
Publishing year
2001
Language
English
Pages
575-580
Publication/Series
Scandinavian Journal of Clinical & Laboratory Investigation
Volume
61
Issue
7
Document type
Journal article
Publisher
Informa Healthcare
Topic
- Medicinal Chemistry
- Pharmacology and Toxicology
- Obstetrics, Gynecology and Reproductive Medicine
Status
Published
ISBN/ISSN/Other
- ISSN: 1502-7686