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Does Allergen-specific Immunotherapy Induce Contact Allergy to Aluminium?

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Author

Summary, in English

Persistent, itching nodules have been reported to appear at the injection site after allergen-specific immuno-therapy with aluminium-precipitated antigen extract, occasionally in conjunction with contact allergy to aluminium. This study aimed to quantify the development of contact allergy to aluminium during allergen-specific immunotherapy. A randomized, controlled, single-blind multicentre study of children and adults entering allergen-specific immunotherapy was performed using questionnaires and patch-testing. A total of 205 individuals completed the study. In the 3 study groups all subjects tested negative to aluminium before allergen-specific immunotherapy and 4 tested positive after therapy. In the control group 4 participants tested positive to aluminium. Six out of 8 who tested positive also had atopic dermatitis. Positive test results were found in 5/78 children and 3/127 adults. Allergen-specific immunotherapy was not shown to be a risk factor for contact allergy to aluminium. Among those who did develop aluminium allergy, children and those with atopic dermatitis were more highly represented.

Publishing year

2013

Language

English

Pages

50-56

Publication/Series

Acta Dermato-Venereologica

Volume

93

Document type

Journal article

Publisher

Medical Journals Limited

Topic

  • Dermatology and Venereal Diseases

Status

Published

Research group

  • Occupational and Environmental Dermatology

ISBN/ISSN/Other

  • ISSN: 1651-2057