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Coevolution of the domains of cytoplasmic tyrosine kinases

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Author

Summary, in English

Many signaling molecules are multidomain proteins that have other domains in addition to the catalytic kinase domain. Protein tyrosine kinases almost without exception contain Src homology 2 (SH2) and/or SH3 domains that can interact with other signaling proteins. Here, we studied evolution of the tyrosine kinases containing SH2 and/or SH3 and kinase domains. The three domains seem to have duplicated together, since the phylogenetic analysis using parsimony gave almost identical evolutionary trees for the separate domains and the multidomain complexes. The congruence analysis of the sequences for the separate domains also suggested that the domains have coevolved. There are several reasons for the domains to appear in a cluster. Kinases are regulated in many ways, and the presence of SH2 and SH3 domains at proper positions is crucial. Because all three domains can recognize different parts of ligands and substrates, their evolution has been interconnected. The reasons for the clustering and coevolution of the three domains in protein tyrosine kinases (PTKs) are discussed.

Publishing year

2001

Language

English

Pages

312-321

Publication/Series

Molecular biology and evolution

Volume

18

Issue

3

Document type

Journal article

Publisher

Oxford University Press

Topic

  • Medical Genetics

Keywords

  • evolution
  • phylogenetics
  • SH2
  • SH3
  • protein kinase
  • tyrosine kinase
  • structural conservation

Status

Published

ISBN/ISSN/Other

  • ISSN: 0737-4038