The browser you are using is not supported by this website. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here: https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc.

RIFINs are adhesins implicated in severe Plasmodium falciparum malaria.

På svenska

Author

  • Suchi Goel
  • Mia Palmkvist
  • Kirsten Moll
  • Nicolas Joannin
  • Patricia Lara
  • Reetesh R Akhouri
  • Nasim Moradi
  • Karin Öjemalm
  • Mattias Westman
  • Davide Angeletti
  • Hanna Kjellin
  • Janne Lehtiö
  • Ola Blixt
  • Lars Ideström
  • Carl G Gahmberg
  • Jill Storry
  • Annika Hult
  • Martin L Olsson
  • Gunnar von Heijne
  • IngMarie Nilsson
  • Mats Wahlgren
Show all

Summary, in English

Rosetting is a virulent Plasmodium falciparum phenomenon associated with severe malaria. Here we demonstrate that P. falciparum-encoded repetitive interspersed families of polypeptides (RIFINs) are expressed on the surface of infected red blood cells (iRBCs), where they bind to RBCs-preferentially of blood group A-to form large rosettes and mediate microvascular binding of iRBCs. We suggest that RIFINs have a fundamental role in the development of severe malaria and thereby contribute to the varying global distribution of ABO blood groups in the human population.

Publishing year

2015

Language

English

Pages

314-317

Publication/Series

Nature Medicine

Volume

21

Issue

4

Document type

Journal article

Publisher

Nature Publishing Group

Topic

  • Hematology

Status

Published

Research group

  • Transfusion Medicine

ISBN/ISSN/Other

  • ISSN: 1546-170X