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Analysis of vesicular trafficking in primary neurons by live imaging.

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Author

Summary, in English

Alzheimer's disease, the most common neurodegenerative disease, is characterized by a progressive loss of synapses and accumulation of amyloid-beta (Aβ) peptides in the brain. Previous studies demonstrated that acute increase in synaptic activity in cultured hippocampal slices and mouse brains (Cirrito et al. Neuron 48: 913-922, 2005; Kamenetz et al. Neuron 37: 925-937, 2003) enhanced secretion of Aβ. Since synaptic activity promotes Aβ secretion, it could also affect the trafficking and processing of its precursor, the amyloid precursor protein (APP). Here, we describe a method to investigate the effect of acute synaptic activation on APP trafficking within dendrites.

Publishing year

2011

Language

English

Pages

343-350

Publication/Series

Methods in Molecular Biology

Volume

793

Document type

Journal article

Publisher

Springer

Topic

  • Neurosciences

Status

Published

Research group

  • Experimental Dementia Research

ISBN/ISSN/Other

  • ISSN: 1940-6029