Active and passive immunization for atherosclerosis
Author
Summary, in English
This review summarizes experimental findings that highlight the role of immune mechanisms in atherosclerosis and the potential atheroprotective effects of active or passive immunization strategies. Immunomodulation therapy appears to be feasible and effective, suggesting that a vaccine for atherosclerosis can be developed for clinical testing. Given the increasing number of patients with atherosclerotic disease on current therapy, a new therapy is needed and an immunization strategy could provide such a possibility. Several questions regarding this approach remain unanswered, however, such as choice of optimal antigens, choice of most effective adjuvants, the optimal route of administration, durability of effects and safety, but cautious optimism remains that a vaccine-based approach has the potential to become a part of the armamentarium for atherosclerotic vascular disease.
Publishing year
2007
Language
English
Pages
176-182
Publication/Series
Current Opinion in Molecular Therapeutics
Volume
9
Issue
2
Links
Document type
Journal article review
Publisher
Thomson Reuters
Topic
- Cardiac and Cardiovascular Systems
Keywords
- immunization
- atherosclerosis
- immune response
- vaccination
Status
Published
Research group
- Cardiovascular Research - Immunity and Atherosclerosis
ISBN/ISSN/Other
- ISSN: 2040-3445