Kinin receptor expression during Staphylococcus aureus infection.

Summary, in English

An inappropriate host response to invading bacteria is a critical parameter that often aggravates the outcome of an infection. Staphylococcus aureus is a major human Gram-positive pathogen that causes a wide array of community- and hospital-acquired diseases ranging from superficial skin infections to severe conditions such as staphylococcal toxic shock. Here we find that S aureus induces inflammatory reactions by modulating the expression and response of the B1 and B2 receptors, respectively. This process is initiated by a chain of events, involving staphylococcal-induced cytokine release from monocytes, bacteria-triggered contact activation, and conversion of bradykinin to its metabolite desArg9bradykinin. The data of the present study implicate an important and previously unknown role for kinin receptor regulation in S aureus infections.

• Author: Sara H Bengtson; Stephen B Phagoo; Anna Norrby-Teglund; Lisa Påhlman; Matthias Mörgelin; Bruce L Zuraw; Fredrik Leeb-Lundberg; Heiko Herwald
• Department/s: Infection Medicine (BMC); Drug Target Discovery
• Publishing year: 2006
• Language: English
• Pages: 2055-2063
• Publication/Series: Blood
• Volume: 108
• Issue: 6
• Full text: - 2 MB; Download statistics
• Links: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16735595&dopt=Abstract; http://dx.doi.org/10.1182/blood-2006-04-016444
• Document type: Journal article
• Publisher: American Society of Hematology
• Topic: Hematology
• Status: Published
• Research group: Drug Target Discovery
• ISBN/ISSN/Other: ISSN: 1528-0020