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Plasma Melatonin Is Reduced in Huntington's Disease

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Author

  • Eirini Kalliolia
  • Edina Silajdzic
  • Rajasree Nambron
  • Nathan R. Hill
  • Anisha Doshi
  • Chris Frost
  • Hilary Watt
  • Peter Hindmarsh
  • Maria Björkqvist
  • Thomas T. Warner

Summary, in English

This study was undertaken to determine whether the production of melatonin, a hormone regulating sleep in relation to the light/dark cycle, is altered in Huntington's disease. We analyzed the circadian rhythm of melatonin in a 24-hour study of cohorts of control, premanifest, and stage II/III Huntington's disease subjects. The mean and acrophase melatonin concentrations were significantly reduced in stage II/III Huntington's disease subjects compared with controls. We also observed a nonsignificant trend toward reduced mean and acrophase melatonin in premanifest Huntington's disease subjects. Onset of melatonin rise was significantly more temporally spread in both premanifest and stage II/III Huntington's disease subjects compared with controls. A nonsignificant trend also was seen for reduced pulsatile secretion of melatonin. Melatonin concentrations are reduced in Huntington's disease. Altered melatonin patterns may provide an explanation for disrupted sleep and circadian behavior in Huntington's disease, and represent a biomarker for disease state. Melatonin therapy may help the sleep disorders seen in Huntington's disease. (c) 2014 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.

Publishing year

2014

Language

English

Pages

1511-1515

Publication/Series

Movement Disorders

Volume

29

Issue

12

Document type

Journal article

Publisher

John Wiley & Sons Inc.

Topic

  • Neurology

Keywords

  • Huntington's disease
  • melatonin
  • circadian rhythm

Status

Published

Research group

  • Biomarkers in Brain Disease

ISBN/ISSN/Other

  • ISSN: 0885-3185