Adiponutrin: A multimeric plasma protein.

Summary, in English

The interest in adiponutrin stems from adiponutrin variant I148M, which is strongly associated to non-alcoholic fatty liver disease. Adiponutrin has to date been considered to be solely an intracellular protein, with a role in lipid metabolism in liver and adipose tissue. However, a physiologically relevant role for adiponutrin has not been found. The aim of this study was to investigate the presence of adiponutrin in human plasma, a new facet of adiponutrin research. We demonstrate that adiponutrin is present in plasma as disulfide-bond dependent multimers, estimated to circulate at a concentration of 1.25-4nM. Experiments reveal that adiponutrin is released from HepG2 cells in the presence of oleate. The presence of adiponutrin in plasma makes it accessible for clinical investigations and use as a potential biomarker for metabolic disease.

• Author: Martin Tinnerfelt Winberg; Mahshid Khalaj Motlagh; Karin Stenkula; Cecilia Holm; Helena Jones
• Department/s: Molecular Endocrinology; Department of Experimental Medical Science; EXODIAB: Excellence of Diabetes Research in Sweden
• Publishing year: 2014
• Language: English
• Pages: 1114-1119
• Publication/Series: Biochemical and Biophysical Research Communications
• Volume: 446
• Issue: 4
• Full text: - 912 kB; Download statistics
• Links: http://www.ncbi.nlm.nih.gov/pubmed/24680680?dopt=Abstract; http://dx.doi.org/10.1016/j.bbrc.2014.03.078
• Document type: Journal article
• Publisher: Elsevier
• Topic: Biological Sciences
• Status: Published
• Research group: Molecular Endocrinology
• ISBN/ISSN/Other: ISSN: 1090-2104