The browser you are using is not supported by this website. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here: https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc.

Probiotics lower plasma glucose in the high-fat fed C57BL/6J mouse.

På svenska

Author

Summary, in English

Today, the gut microbiota is considered a key organ in host nutritional metabolism and recent data have suggested that alterations in gut microbiota contribute to the development of type 2 diabetes and obesity. Accordingly, a whole range of beneficial effects relating to inflammation and gut health have been observed following administration of probiotics to both humans and different animal models. The objective of this study was to evaluate the metabolic effects of an oral probiotic supplement, Lactobacillus plantarum DSM 15313, to high-fat diet (HFD) fed C57BL/6J mice, a model of human obesity and early diabetes. The mice were fed the experimental diets for 20 weeks, after which the HFD had induced an insulin-resistant state in both groups compared to the start of the study. The increase in body weight during the HFD feeding was higher in the probiotic group than in the control group, however, there were no significant differences in body fat content. Fasting plasma glucose levels were lower in the group fed the probiotic supplement, whereas insulin and lipids were not different. Caecal levels of short-chain fatty acids were not significantly different between the groups. An oral glucose tolerance test showed that the group fed probiotics had a significantly lower insulin release compared to the control group, although the rate of glucose clearance was not different. Taken together, these data indicate that L. plantarum DSM 15313 has anti-diabetic properties when fed together with an HFD.

Publishing year

2010

Language

English

Pages

189-196

Publication/Series

Beneficial microbes

Volume

1

Issue

2

Document type

Journal article

Publisher

Wageningen Academic Publishers

Topic

  • Endocrinology and Diabetes

Keywords

  • Volatile: analysis * Lactobacillus plantarum: physiology * Obesity: prevention & control * Plasma: chemistry * Probiotics: administration & dosage
  • * Body Weight: physiology * Adipose Tissue: physiology * Cecum: chemistry * Diabetes Mellitus: prevention & control * Diet: methods * Fats: administration & dosage * Fatty Acids

Status

Published

Project

  • ANTIDIABETIC FOOD CENTRE

Research group

  • Molecular Endocrinology

ISBN/ISSN/Other

  • ISSN: 1876-2891