CD81 and CD48 show different expression on blood eosinophils in systemic sclerosis: new markers for disease and pulmonary inflammation?

Summary, in English

In systemic sclerosis (SSc)-related interstitial lung disease (ILD), elevated eosinophil counts in bronchoalveolar lavage are associated with a worse outcome. We hypothesized that eosinophils may be activated in the peripheral circulation, thereby increasing their recruitment to affected tissues and contributing to inflammation and fibrosis. The aim of this study was to characterize the blood eosinophils in SSc patients.

• Author: Dirk Wuttge; A Andreasson; Ellen Tufvesson; Å Johansson; Agneta Scheja; Thomas Hellmark; Roger Hesselstrand; Lennart Truedsson
• Department/s: Rheumatology; Lung physiology and biomarkers; Respiratory Medicine, Allergology, and Palliative Medicine; Nephrology; Autoimmunity and kidney diseases; Division of Microbiology, Immunology and Glycobiology - MIG
• Publishing year: 2016
• Language: English
• Pages: 107-113
• Publication/Series: Scandinavian Journal of Rheumatology
• Volume: 45
• Issue: 2
• Full text: - 13 MB; Download statistics
• Links: http://www.ncbi.nlm.nih.gov/pubmed/26926492?dopt=Abstract; http://dx.doi.org/10.3109/03009742.2015.1054877
• Document type: Journal article
• Publisher: Taylor & Francis
• Topic: Respiratory Medicine and Allergy
• Status: Published
• Research group: Lung physiology and biomarkers; Autoimmunity and kidney diseases
• ISBN/ISSN/Other: ISSN: 1502-7732