Relationships among serum cystatin C, serum creatinine, lean tissue mass and glomerular filtration rate in healthy adults
Author
Summary, in English
In an effort to increase our knowledge of the optimal use of serum cystatin C and creatinine as glomerular filtration rate (GFR) markers, these variables, as well as lean tissue mass and GFR, were determined in a population of 42 healthy young adults (men and women with normal GFR). Dual-energy X-ray absorptiometry and measurement of the plasma clearance of iohexol were used to measure lean tissue mass and GFR, respectively. Serum creatinine was significantly correlated to lean tissue mass (r=0.65; p < 0.0001) but not to GFR (1/creatinine vs. GFR: r=0.11; p=0.106). In contrast, serum cystatin C correlated with GFR (1/cystatin C vs. GFR: r=0.32; p=0.0387), especially in men (1/cystatin C vs. GFR: r=0.64; p=0.0055), but not to lean tissue mass. These results might explain previous observations that serum cystatin C seems to be a better marker for GFR than serum creatinine, particularly for individuals with small to moderate decreases in GFR. However, the results also show that the serum concentrations of both creatinine and cystatin C are determined not only by GFR, but also by other factors. Since these additional factors differ for cystatin C and creatinine, it seems justified to use serum creatinine and cystatin C in conjunction to estimate GFR, at least until it is known in what situations serum creatinine or cystatin C is the preferable marker.
Publishing year
1999
Language
English
Pages
587-592
Publication/Series
Scandinavian Journal of Clinical & Laboratory Investigation
Volume
59
Issue
8
Document type
Journal article
Publisher
Informa Healthcare
Topic
- Medicinal Chemistry
- Pharmacology and Toxicology
- Urology and Nephrology
Keywords
- Sex characteristics
Status
Published
ISBN/ISSN/Other
- ISSN: 1502-7686