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Small Randomized Trial Among Low-Birth-Weight Children Receiving Bacillus Calmette-Guerin Vaccination First Health Center Contact

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Author

  • Sofie Biering-Sorensen
  • Peter Aaby
  • Bitiguida Mutna Napirna
  • Adam Roth
  • Henrik Ravn
  • Amabelia Rodrigues
  • Hilton Whittle
  • Christine Stabell Benn

Summary, in English

A total of 105 low-birth-weight children presenting for first vaccination were randomized to receive bacillus Calmette-Guerin (BCG) immediately or later (current practice). The mortality rate ratio for BCG was 0.17 (95% CI = 0.02-1.35) within 3 days of enrollment, 0.28 (0.06-1.37) in the first month, and 0.27 (0.07-0.98) after 2 months of age. The mortality rate ratio was 0.41 (0.14-1.18) (P = 0.098) in infancy. Administration of BCG vaccine at first contact may contribute to lower mortality.

Publishing year

2012

Language

English

Pages

306-308

Publication/Series

Pediatric Infectious Disease Journal

Volume

31

Issue

3

Document type

Journal article

Publisher

Lippincott Williams & Wilkins

Topic

  • Microbiology in the medical area

Keywords

  • vaccines
  • nonspecific effects of
  • neonatal mortality
  • infant mortality
  • BCG

Status

Published

Research group

  • Clinical Microbiology, Malmö

ISBN/ISSN/Other

  • ISSN: 1532-0987