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α-l-FucosyItransferases in Human Serum from Donors of Different ABO, Secretor and Lewis Blood-Group Phenotypes

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Author

  • Helmut Schenkel-Brunner
  • Alan Chester
  • Winifred M Watkins

Summary, in English

The presence of α-l-fucosyltransferases in human serum of different ABO, secretor and Lewis blood-group phenotypes was investigated with guanosine diphosphate fucose as the sugar donor and low-molecular-weight oligosaccharides, or a macromolecular glycoprotein, as acceptors. In contrast to the α-2-l-fucosyltransferases in human milk, submaxillary glands and stomach mucosa that occur only in ABH secretors, an enzyme that transfers l-fucose to the C-2 position of non-reducing β-galactosyl residues was found in the serum of all normal ABO donors irrespective of their ABH secretor-nonsecretor status. The only sera in which the α-2-l-fucosyltransferase was not demonstrable were three examples of the blood group Bombay Oh phenotype and one example of the Bh phenotype. An a-3-l-fucosyltransferase that conveyed L-fucose to the C-3 position in N-acetyl-d-glucosamine or d-glucose occurred in all the sera examined including those from donors of the Bombay Oh and Bh phenotypes. a-4-l-Fucosyltransferase activity was virtually absent from the sera, irrespective of the Lewis blood group of the donors.

Publishing year

1972

Language

English

Pages

269-277

Publication/Series

European Journal of Biochemistry

Volume

30

Issue

2

Document type

Journal article

Publisher

Wiley-Blackwell

Topic

  • Hematology

Status

Published

ISBN/ISSN/Other

  • ISSN: 0014-2956