Thyroid autoimmunity in relation to islet autoantibodies and HLA-DQ genotype in newly diagnosed type 1 diabetes in children and adolescents.

Summary, in English

AIMS/HYPOTHESIS: The aim of this work was to investigate, in children newly diagnosed with type 1 diabetes: (1) the prevalence of autoantibodies against thyroid peroxidase (TPOAb) and thyroglobulin (TGAb); and (2) the association between TPOAb, TGAb or both, with either islet autoantibodies or HLA-DQ genes. METHODS: Blood samples from 2,433 children newly diagnosed with type 1 diabetes were analysed for TPOAb and TGAb in addition to autoantibodies against arginine zinc transporter 8 (ZnT8RA), tryptophan zinc transporter 8 (ZnT8WA), glutamine zinc transporter 8 (ZnT8QA), glutamic acid decarboxylase (GADA), insulin (IAA), insulinoma-associated protein-2 (IA-2A), HLA-DQA-B1 genotypes, thyroid-stimulating hormone (TSH) and free thyroxine (T4). RESULTS: At type 1 diabetes diagnosis, 12% of the children had thyroid autoantibodies (60% were girls; p < 0.0001). GADA was positively associated with TPOAb (p < 0.001) and with TGAb (p < 0.001). In addition, ZnT8A was associated with both TPOAb (p = 0.039) and TGAb (p = 0.015). DQB1*05:01 in any genotype was negatively associated with TPOAb (OR 0.55, 95% CI 0.37, 0.83, p value corrected for multiple comparisons (p c) = 0.012) and possibly with TGAb (OR 0.55, 95% CI 0.35, 0.87, p c = 0.07). Thyroid autoimmunity in children newly diagnosed with type 1 diabetes was rarely (0.45%) associated with onset of clinical thyroid disease based on TSH and free T4. CONCLUSIONS/INTERPRETATION: GADA and ZnT8A increased the risk for thyroid autoimmunity at the time of clinical diagnosis of type 1 diabetes, while HLA-DQB1*05:01 reduced the risk. However, the associations between thyroid autoimmunity and HLA-DQ genotype were weak and did not fully explain the co-occurrence of islet and thyroid autoimmunity.

• Author: Berglind Jonsdottir; Cecilia K Andersson; Annelie Carlsson; Ahmed Delli; G Forsander; J Ludvigsson; C Marcus; Ulla Samuelsson; E Ortqvist; Åke Lernmark; S-A Ivarsson; H Elding Larsson
• Department/s: Paediatric Endocrinology; Paediatrics (Lund); Celiac Disease and Diabetes Unit; Brain Repair and Imaging in Neural Systems (BRAINS); EXODIAB: Excellence of Diabetes Research in Sweden
• Publishing year: 2013
• Language: English
• Pages: 1735-1742
• Publication/Series: Diabetologia
• Volume: 56
• Issue: 8
• Full text: - 291 kB; Download statistics
• Links: http://www.ncbi.nlm.nih.gov/pubmed/23666211?dopt=Abstract; http://dx.doi.org/10.1007/s00125-013-2934-9
• Document type: Journal article
• Publisher: Springer
• Topic: Endocrinology and Diabetes
• Status: Published
• Research group: Paediatric Endocrinology; Celiac Disease and Diabetes Unit; Brain Repair and Imaging in Neural Systems (BRAINS)
• ISBN/ISSN/Other: ISSN: 1432-0428