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Predominance of caudate nucleus lesions in acute ischemic stroke patients with impairments in language and speech

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Author

Summary, in English

Background and purpose. Whereas traditional views of language processing in the brain have assumed that the language function is concentrated to a limited number of cortical areas (Broca’s and Wernicke’s areas), current knowledge points at a much more complex system of language and speech processing involving many brain areas, both cortical and subcortical. The purpose of the current study was to make an unbiased assessment of which cerebral areas are affected in first-ever acute ischemic stroke patients identified as having language and speech impairments according to the National Institute of Health Stroke Scale (NIHSS).

Methods. Data from thirty-four patients with language and speech impairments, with a score of 1-3 on item 9 on the NIHSS, following ischemic stroke was collected from the Lund Stroke Register. MRI images acquired up to 20 days after stroke onset were used to create an overlap lesion image using MRIcron software.

Results. The classical language areas, Wernicke’s and Broca’s area, were affected in less than one fourth of the patients. The most frequently affected region was a subcortical region - the left caudate nucleus and the adjacent corona radiata.

Conclusions. These findings contribute to the growing body of evidence that the basal ganglia have a crucial role in the control over language and speech processing.

Publishing year

2016

Language

English

Pages

148-153

Publication/Series

European Journal of Neurology

Volume

23

Issue

1

Document type

Journal article

Publisher

Wiley-Blackwell

Topic

  • Radiology, Nuclear Medicine and Medical Imaging
  • General Language Studies and Linguistics
  • Neurology

Keywords

  • caudate nucleus
  • stroke
  • speech
  • language
  • MRI
  • basal ganglia

Status

Published

Project

  • Humanities and Medicine (HuMe)
  • Images of tones: fMRI-studies on the processing of prosody in the human brain

Research group

  • Clinical Stroke Research Group

ISBN/ISSN/Other

  • ISSN: 1351-5101