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SERCA-inhibiting activity of C-19 terpenolides from Thapsia garganica and their possible biogenesis

På svenska

Author

  • G Appendino
  • S Prosperini
  • Carola Valdivia
  • M Ballero
  • G Colombano
  • R A Billington
  • A A Genazzani
  • Olov Sterner

Summary, in English

An investigation of Thapsia garganica afforded a series of tetracyclic C-19 dilactones, whose production was dependent on the time and location of the collection. These unusual tetrahomosesquiterpenoids are presumably biosynthesized via a carbon dioxide-triggered electrophilic polyolefin cyclization. Despite the structural differences with thapsigargin, these compounds showed SERCA-inhibiting properties.

Publishing year

2005

Language

English

Pages

1213-1217

Publication/Series

Journal of Natural Products

Volume

68

Issue

8

Document type

Journal article

Publisher

The American Chemical Society (ACS)

Topic

  • Organic Chemistry

Status

Published

ISBN/ISSN/Other

  • ISSN: 0163-3864