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The relationship between different forms of human alpha-mannosidase

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Author

  • Alan Chester
  • A Lundblad
  • P K Masson

Summary, in English

The tissue distribution and some properties of human alpha-mannosidase (alpha-D-mannoside mannohydrolase EC 3.2.1.24) have been studied. The acidic forms of the enzyme were fairly stable, whereas the neutral forms easily lost enzymic activity. The acidic forms were sensitive to neuraminidase but the neutral forms were unaffected. The experiments indicate that the acidic components are closely related to each other, differing only in sialic acid content and possibly conformation. The neutral forms of the enzyme are probably quite different from the acidic forms both in structure and cellular function.

Publishing year

1975

Language

English

Pages

341-348

Publication/Series

Biochimica et Biophysica Acta

Volume

391

Issue

2

Document type

Journal article

Publisher

Elsevier

Topic

  • Biological Sciences

Status

Published

ISBN/ISSN/Other

  • ISSN: 0006-3002