Different outcome of allogeneic transplantation in myelofibrosis using conventional or reduced-intensity conditioning regimens

Summary, in English

Allogeneic haematopoietic stem cell transplantation remains the only curative treatment of myelofibrosis with myeloid metaplasia (MMM). Previous reports have indicated significant treatment-related mortality (TRM) for patients transplanted after myeloablative conditioning but superior survival has been reported after reduced-intensity conditioning (RIC). We report the results of a survey of all allogeneic transplantations for MMM performed in Sweden at six transplant units between 1982 and 2004. Twenty-seven patients were transplanted; 17 with a myeloablative conditioning regimen and 10 with RIC. The median age was 50 years (5-63 years) at transplantation. After a median follow up of 55 months, 20 patients are alive. TRM was 10% in the RIC group and 30% in the myeloablative group. There was no difference in survival for high or low-risk patients according to Cervantes score or between sibling and unrelated donor transplantations.

• Author: Mats Merup; Vladimir Lazarevic; Hareth Nahi; Bjorn Andreasson; Claes Malm; Lars Nilsson; Mats Brune; Katarina LeBlanc; Jack Kutti; Gunnar Birgegard
• Department/s: Department of Laboratory Medicine
• Publishing year: 2006
• Language: English
• Pages: 367-373
• Publication/Series: British Journal of Haematology
• Volume: 135
• Issue: 3
• Links: http://dx.doi.org/10.1111/j.1365-2141.2006.06302.x
• Document type: Journal article
• Publisher: Wiley-Blackwell
• Topic: Hematology
• Keywords: conditioning; reduced intensity; myelofibrosis; allogeneic transplantation; Cervantes score
• Status: Published
• ISBN/ISSN/Other: ISSN: 0007-1048