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Distinct inflammatory mediator patterns characterize infectious and sterile systemic inflammation in febrile neutropenic hematology patients.

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Author

  • Christine Wennerås
  • Lars Hagberg
  • Rune Andersson
  • Lars Hynsjö
  • Anders Lindahl
  • Marcin Okroj
  • Anna Blom
  • Peter Johansson
  • Björn Andreasson
  • Johan Gottfries
  • Agnes E Wold
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Summary, in English

Invasive infections and sterile tissue damage can both give rise to systemic inflammation with fever and production of inflammatory mediators. This makes it difficult to diagnose infections in patients who are already inflamed, e.g. due to cell and tissue damage. For example, fever in patients with hematological malignancies may depend on infection, lysis of malignant cells, and/or chemotherapy-induced mucosal damage. We hypothesized that it would be possible to distinguish patterns of inflammatory mediators characterizing infectious and non-infectious causes of inflammation, respectively. Analysis of a broad range of parameters using a multivariate method of pattern recognition was done for this purpose.

Department/s

Publishing year

2014

Language

English

Publication/Series

PLoS ONE

Volume

9

Issue

3

Document type

Journal article

Publisher

Public Library of Science (PLoS)

Topic

  • Other Basic Medicine

Status

Published

Research group

  • Protein Chemistry, Malmö

ISBN/ISSN/Other

  • ISSN: 1932-6203