Effects of arsenic trioxide and hypoxia in multidrug-resistant neuroblastoma
Author
Summary, in English
In order to mimic growth conditions in a solid tumour, neuroblastoma cells were grown at hypoxia in presence or absence of glucose. Growth in absence of glucose induced cell death at normoxia conditions, but growth at hypoxic conditions could inhibit the glucose-deficiency induced cell death. Hypoxic growth conditions seem to rescue the cells through inhibiting glucose-deficiency induced activation of caspases and through induced expression of survival-promoting factors signalling through the MAPK-pathway.
Department/s
Publishing year
2005
Language
English
Publication/Series
Lund University Faculty of Medicine Doctoral Dissertation Series
Document type
Dissertation
Publisher
Lund University: Faculty of Medicine
Topic
- Cancer and Oncology
Keywords
- Klinisk biologi
- Clinical biology
- neuroblastoma
- multidrug resistance
- hypoxia
- glucose-deficiency
- cell death
- Bax
- Apoptosis
- arsenic trioxide
Status
Published
Supervisor
ISBN/ISSN/Other
- ISSN: 1652-8220
- ISBN: 91-85439-54-1
Defence date
3 June 2005
Defence time
09:15
Defence place
Main lecture hall, Pathology building, Malmö university hospital
Opponent
- Maria Shoshan (Associate Professor)