Variation in the MC4R Gene Is Associated with Bone Phenotypes in Elderly Swedish Women.
Author
Summary, in English
Osteoporosis is characterized by reduced bone mineral density (BMD) and increased fracture risk. Fat mass is a determinant of bone strength and both phenotypes have a strong genetic component. In this study, we examined the association between obesity associated polymorphisms (SNPs) with body composition, BMD, Ultrasound (QUS), fracture and biomarkers (Homocysteine (Hcy), folate, Vitamin D and Vitamin B12) for obesity and osteoporosis. Five common variants: rs17782313 and rs1770633 (melanocortin 4 receptor (MC4R); rs7566605 (insulin induced gene 2 (INSIG2); rs9939609 and rs1121980 (fat mass and obesity associated (FTO) were genotyped in 2 cohorts of Swedish women: PEAK-25 (age 25, n = 1061) and OPRA (age 75, n = 1044). Body mass index (BMI), total body fat and lean mass were strongly positively correlated with QUS and BMD in both cohorts (r(2) = 0.2-0.6). MC4R rs17782313 was associated with QUS in the OPRA cohort and individuals with the minor C-allele had higher values compared to T-allele homozygotes (TT vs. CT vs.
Department/s
- Orthopedics - Clinical and Molecular Osteoporosis Research
- Diabetes - Clinical Obesity
- Genetics
- EpiHealth: Epidemiology for Health
Publishing year
2014
Language
English
Publication/Series
PLoS ONE
Volume
9
Issue
2
Full text
- Available as PDF - 185 kB
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Links
Document type
Journal article
Publisher
Public Library of Science (PLoS)
Topic
- Nutrition and Dietetics
- Medical Genetics
- Orthopedics
Status
Published
Research group
- Orthopedics - Clinical and Molecular Osteoporosis Research
- Diabetes - Clinical Obesity
- Genetics
ISBN/ISSN/Other
- ISSN: 1932-6203