Research in motion: the enigma of Parkinson's disease pathology spread.
Author
Summary, in English
Neuropathological changes in Parkinson's disease progress slowly and spread according to a characteristic pattern. Recent papers have shed light on this progression of pathology by examining the fate of neurons grafted into the brains of patients with Parkinson's disease. Two of these studies demonstrate that grafted healthy neurons can gradually develop the same pathology as host neurons in the diseased brains. According to these studies, implanted neurons developed alpha-synuclein- and ubiquitin-positive Lewy bodies more than a decade after transplantation. We discuss the possible underlying mechanisms and their implications for how pathology spreads in Parkinson's disease.
Department/s
- Department of Experimental Medical Science
- Neural Plasticity and Repair
- Neurogenesis and cell therapy
- Neurology, Lund
Publishing year
2008
Language
English
Pages
741-745
Publication/Series
Nature Reviews Neuroscience
Volume
9
Issue
10
Links
Document type
Journal article review
Publisher
Nature Publishing Group
Topic
- Neurosciences
Status
Published
Research group
- Neural Plasticity and Repair
- Neurogenesis and cell therapy
ISBN/ISSN/Other
- ISSN: 1471-003X