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Variety in vegetable and fruit consumption and risk of bladder cancer in the European Prospective Investigation into Cancer and Nutrition

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Author

  • Frederike L. Buchner
  • H. Bas Bueno-de-Mesquita
  • Martine M. Ros
  • Ellen Kampman
  • Lars Egevad
  • Kim Overvad
  • Anne Tjonneland
  • Nina Roswall
  • Francoise Clavel-Chapelon
  • Marie-Christine Boutron-Ruault
  • Marina Touillaud
  • Rudolf Kaaks
  • Jenny Chang-Claude
  • Heiner Boeing
  • Steffen Weikert
  • Antonia Trichopoulou
  • Ada Naska
  • Vicky Benetou
  • Domenico Palli
  • Sabina Sieri
  • Paolo Vineis
  • Rosario Tumino
  • Salvatore Panico
  • Franzel J. B. van Duijnhoven
  • Petra H. M. Peeters
  • Carla H. van Gils
  • Eiliv Lund
  • Inger T. Gram
  • Maria-Jose Sanchez
  • Paula Jakszyn
  • Nerea Larranaga
  • Eva Ardanaz
  • Carmen Navarro
  • Laudina Rodriguez
  • Jonas Manjer
  • Roy Ehrnström
  • Goran Hallmans
  • Borje Ljungberg
  • Tim J. Key
  • Naomi E. Allen
  • Kay-Tee Khaw
  • Nicholas Wareham
  • Nadia Slimani
  • Mazda Jenab
  • Paolo Boffetta
  • Lambertus A. L. M. Kiemeney
  • Elio Riboli
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Summary, in English

Recent research does not show an association between fruit and vegetable consumption and bladder cancer risk. None of these studies investigated variety in fruit and vegetable consumption, which may capture different aspects of consumption. We investigated whether a varied consumption of vegetables and fruits is associated with bladder cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Detailed data on food consumption and complete follow-up for cancer incidence were available for 452,185 participants, who were recruited from ten European countries. After a mean follow-up of 8.7 years, 874 participants were diagnosed with bladder cancer. Diet diversity scores (DDSs) were used to quantify the variety in fruit and vegetable consumption. Multivariable Cox proportional hazard models were used to assess the effect of the DDSs on bladder cancer risk. There was no evidence of a statistically significant association between bladder cancer risk and any of the DDSs when these scores were considered as continuous covariates. However, the hazard ratio (HR) for the highest tertile of the DDS for combined fruit and vegetable consumption was marginally significant compared to the lowest (HR = 1.30, 95% confidence interval: 1.00-1.69, p-trend = 0.05). In EPIC, there is no clear association between a varied fruit and vegetable consumption and bladder cancer risk. This finding provides further evidence for the absence of any strong association between fruit and vegetable consumption as measured by a food frequency questionnaire and bladder cancer risk.

Publishing year

2011

Language

English

Pages

2971-2979

Publication/Series

International Journal of Cancer

Volume

128

Issue

12

Document type

Journal article

Publisher

John Wiley & Sons Inc.

Topic

  • Cancer and Oncology

Keywords

  • bladder cancer
  • DDS
  • fruit
  • vegetables
  • EPIC

Status

Published

Research group

  • Surgery
  • Pathology, Malmö

ISBN/ISSN/Other

  • ISSN: 0020-7136