Presence of High-Risk HPV mRNA in Relation to Future High-Grade Lesions among High-Risk HPV DNA Positive Women with Minor Cytological Abnormalities.

Summary, in English

Continuous expression of E6- and E7-oncogenes of high-risk human papillomavirus (HPV) types is necessary for the development and maintenance of the dysplastic phenotype. The aim of the study was to determine the sensitivity and specificity of the APTIMA HPV mRNA assay (Hologic) in predicting future development of high-grade cervical intraepithelial neoplasia (CIN) among high-risk HPV-DNA-positive women with atypical squamous cells of undetermined significance (ASCUS) or low-grade squamous epithelial lesion (LSIL) cytology.

• Author: Hanna K Johansson; Kaj Bjelkenkrantz; Lotten Darlin; Joakim Dillner; Ola Forslund
• Department/s: Clinical Microbiology, Malmö; Pathology, Malmö; Obstetrics and Gynaecology (Lund)
• Publishing year: 2015
• Language: English
• Publication/Series: PLoS ONE
• Volume: 10
• Issue: 4
• Full text: - 160 kB; Download statistics
• Links: http://www.ncbi.nlm.nih.gov/pubmed/25893988?dopt=Abstract; http://dx.doi.org/10.1371/journal.pone.0124460
• Document type: Journal article
• Publisher: Public Library of Science (PLoS)
• Topic: Microbiology in the medical area; Cell and Molecular Biology; Cancer and Oncology
• Status: Published
• Research group: Clinical Microbiology, Malmö; Pathology, Malmö
• ISBN/ISSN/Other: ISSN: 1932-6203