The water-perfusable tissue fraction of colorectal cancer metastases is increased by the selective PDGF-receptor inhibitor imatinib but not the IL-1 receptor antagonist anakinra, a study using serial dynamic 15O-water PET.

Summary, in English

High interstitial fluid pressure (IFP) in colorectal cancer metastases may decrease the uptake and, thus, the effects of anti-tumor drugs. Imatinib, a selective inhibitor of PDGF receptors, and anakinra, an interleukin-1 receptor antagonist, respectively, increase drug uptake and/or decrease IFP in preclinical models of carcinoma. Drug-induced decrease in IFP in human metastases has not been objectively shown, but should be reflected by an increase in water-perfusable tissue fraction (PTF) or tumor blood flow (TBF) using [(15)O]water PET/CT and kinetic modelling. Hence, the aim of this study was to assess the effects of imatinib and anakinra on PTF and TBF in colorectal cancer metastases in patients.

• Author: Mark Lubberink; Sandeep S V Golla; My Jonasson; Kristofer Rubin; Bengt Glimelius; Jens Sörensen; Peter Nygren
• Department/s: Division of Translational Cancer Research
• Publishing year: 2015
• Language: English
• Pages: 1144-1149
• Publication/Series: Journal of Nuclear Medicine
• Volume: 56
• Issue: 8
• Links: http://www.ncbi.nlm.nih.gov/pubmed/26069310?dopt=Abstract; http://dx.doi.org/10.2967/jnumed.114.151894
• Document type: Journal article
• Publisher: Society of Nuclear Medicine
• Topic: Cancer and Oncology
• Status: Published
• ISBN/ISSN/Other: ISSN: 0161-5505