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Lipopolysaccharide-Induced Loss of Cultured Rat Myenteric Neurons - Role of AMP-Activated Protein Kinase.

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Author

Summary, in English

Intestinal barrier function is vital for homeostasis. Conditions where the mucosal barrier is compromised lead to increased plasma content of lipopolysaccharide (LPS). LPS acts on Toll-like receptor 4 (TLR4) and initiates cellular inflammatory responses. TLR4 receptors have been identified on enteric neurons and LPS exposure causes neuronal loss, counteracted by vasoactive intestinal peptide (VIP), by unknown mechanisms. In addition AMP activated protein kinase (AMPK) stimulation causes loss of enteric neurons. This study investigated a possible role of AMPK activation in LPS-induced neuronal loss.

Department/s

  • Neurogastroenterology

Publishing year

2014

Language

English

Publication/Series

PLoS ONE

Volume

9

Issue

12

Document type

Journal article

Publisher

Public Library of Science (PLoS)

Topic

  • Gastroenterology and Hepatology

Status

Published

Research group

  • Neurogastroenterology

ISBN/ISSN/Other

  • ISSN: 1932-6203