Transcription factor 7-like 2 (TCF7L2)
Author
Summary, in English
In 2006 a genetic signal within the gene encoding transcription factor 7-like 2 (TCF7L2) was first reported to be associated with type 2 diabetes. Since then multiple genome-wide association studies have revealed this signal to be among the most strongest associations reported with this disease to date. Furthermore, multiple studies around the world have revealed the global relevance of this locus in intron 3 of the gene and have helped pinpoint, with relative confidence, the causal lesion at this locus. However, despite this association being beyond doubt, there is still a lack of consensus with respect to mechanisms of action and which tissue(s) it actually exerts its influence on the pathogenesis of type 2 diabetes.
Publishing year
2016-01-01
Language
English
Pages
297-316
Publication/Series
The Genetics of Type 2 Diabetes and Related Traits: Biology, Physiology and Translation
Document type
Book chapter
Publisher
Springer International Publishing
Topic
- Medical Genetics
Status
Published
Research group
- Genomics, Diabetes and Endocrinology
ISBN/ISSN/Other
- ISBN: 9783319015743
- ISBN: 9783319015736