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Heparan sulphate proteoglycans: the sweet side of development.

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Author

Summary, in English

Pattern formation during development is controlled to a great extent by a small number of conserved signal transduction pathways that are activated by extracellular ligands such as Hedgehog, Wingless or Decapentaplegic. Genetic experiments have identified heparan sulphate proteoglycans (HSPGs) as important regulators of the tissue distribution of these extracellular signalling molecules. Several recent reports provide important new insights into the mechanisms by which HSPGs function during development.

Publishing year

2005

Language

English

Pages

530-541

Publication/Series

Nature Reviews. Molecular Cell Biology

Volume

6

Issue

7

Document type

Journal article review

Publisher

Nature Publishing Group

Topic

  • Basic Medicine

Keywords

  • Glycosaminoglycans: biosynthesis
  • Gene Expression Regulation
  • Animals
  • N.I.H.
  • U.S. Gov't
  • P.H.S.
  • Signal Transduction
  • Non-U.S. Gov't
  • Research Support
  • Extramural
  • Heparan Sulfate Proteoglycan: genetics
  • Heparan Sulfate Proteoglycan: physiology
  • Humans
  • Mutation

Status

Published

Research group

  • Invertebrate Developmental Biology, Udo Haecker's group

ISBN/ISSN/Other

  • ISSN: 1471-0072