The browser you are using is not supported by this website. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here: https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc.

Small intestinal CD103(+) dendritic cells display unique functional properties that are conserved between mice and humans

På svenska

Author

  • Elin Jaensson Gyllenbäck
  • Heli Uronen-Hansson
  • Oliver Pabst
  • Bertus Eksteen
  • Jiong Tian
  • Janine L. Coombes
  • Pia-Lena Berg
  • Thomas Davidsson
  • Fiona Powrie
  • Bengt Johansson Lindbom
  • William Agace
Show all

Summary, in English

A functionally distinct subset of CD103(+) dendritic cells (DCs) has recently been identified in murine mesenteric lymph nodes (MLN) that induces enhanced FoxP3(+) T cell differentiation, retinoic acid receptor signaling, and gut-homing receptor (CCR9 and alpha 4 beta 7) expression in responding T cells. We show that this function is specific to small intestinal lamina propria (SI-LP) and MLN CD103(+) DCs. CD103(+) SI-LP DCs appeared to derive from circulating DC precursors that continually seed the SI- LP. BrdU pulse-chase experiments suggested that most CD103(+) DCs do not derive from a CD103(-) SI- LP DC intermediate. The majority of CD103(+) MLN DCs appear to represent a tissue- derived migratory population that plays a central role in presenting orally derived soluble antigen to CD8(+) and CD4(+) T cells. In contrast, most CD103(+) MLN DCs appear to derive from blood precursors, and these cells could proliferate within the MLN and present systemic soluble antigen. Critically, CD103(+) DCs with similar phenotype and functional properties were present in human MLN, and their selective ability to induce CCR9 was maintained by CD103(+) MLN DCs isolated from SB Crohn ' s patients. Thus, small intestinal CD103(+) DCs represent a potential novel target for regulating human intestinal infl ammatory responses.

Department/s

Publishing year

2008

Language

English

Pages

2139-2149

Publication/Series

Journal of Experimental Medicine

Volume

205

Issue

9

Document type

Journal article

Publisher

Rockefeller University Press

Topic

  • Immunology in the medical area

Status

Published

Research group

  • Immunology
  • Urology

ISBN/ISSN/Other

  • ISSN: 1540-9538