Electronic speckle pattern interferometry: A novel non-invasive tool for studying drug transport rate through free films
Author
Summary, in English
In this work, Electronic Speckle Pattern Interferometry (ESPI) is presented as a non-invasive tool to study drug transport in controlled release systems. ESPI is shown to be a feasible tool to measure drug film permeability via comparison with an ordinary diaphragm cell. A specially designed cuvette was used in the release study: the polymeric film separated the donor and the receiving chambers of the cuvette to create a diffusion cell with no mixing in the two chambers. Thus, the cuvette mimicked a coated system immersed in a stagnant bulk liquid. Concentration profile data were obtained for the two compartments. Using these data, it was possible to visually discriminate between a film subject only to diffusion and a film subject to diffusion as well as osmotic effects. Moreover, using the concentration profile data collected at different time intervals, it was possible to follow the film properties in terms of drug permeability, thus studying bow drug permeability depended on drug concentration. Compared to other measuring techniques, ESPI offers the advantages that no invasive measurements are needed, and that no sampling and calibration are required. Furthermore, the permeability can be measured with no influence of mass transfer in the boundary layers. (c) 2006 Elsevier B.V. All rights reserved.
Department/s
Publishing year
2006
Language
English
Pages
369-380
Publication/Series
Journal of Controlled Release
Volume
114
Issue
3
Document type
Journal article
Publisher
Elsevier
Topic
- Chemical Engineering
Keywords
- ESPI interferometry
- osmosis
- drug release
- membrane
- diffusion
Status
Published
ISBN/ISSN/Other
- ISSN: 1873-4995