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Low expression of CysLT(1)R and high expression of CysLT(2)R mediate good prognosis in colorectal cancer

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Author

Summary, in English

Colorectal cancer is the third most common cancer type in the western world. in search of new treatment possibilities, the inflammation mediators, know as cysteinyl leukotrienes (CysLTs), have been shown to regulate intestinal epithelial cell survival and proliferation via the CysLT(1)R, and cell differentiation via the CysLT(2)R. These results prompted us to investigate the significance of CysLT(1)R and CysLT(2)R expression in colorectal cancer tissue for patient survival. The CysLT(1)R, CysLT(2)R, beta-catenin and Bcl-xL protein expression levels were evaluated by immunohistochemistry in a tissue microarray of 329 colorectal patients. We found that high nuclear expression of CysLT(1)R is associated with a poor prognosis, whereas high nuclear expression of CysLT(2)R is associated with a good prognosis. We also observed that patients with colorectal tumours characterised by high CysLT(1)R but low CysLT(2)R nuclear expression had the lowest survival expectancy, whereas patients with colorectal tumours characterised by low CysLT(1)R but high CysLT(2)R nuclear expression had the best survival expectancy. Interestingly, beta-catenin as a single prognostic marker did not exhibit any prognostic value. However, in patients with tumours characterised by a high CysLT(1)R nuclear expression, an elevated beta-catenin nuclear expression had a significantly prognostic value. In conclusion these data indicate that nuclear expressions of CysLTRs are potential prognostic indicators of colorectal cancer. (C) 2009 Elsevier Ltd. All rights reserved.

Department/s

Publishing year

2010

Language

English

Pages

826-835

Publication/Series

European Journal of Cancer

Volume

46

Issue

4

Document type

Journal article

Publisher

Elsevier

Topic

  • Cancer and Oncology

Keywords

  • Colorectal cancer
  • beta-Catenin
  • CysLT(1)R
  • CysLT(2)R

Status

Published

Research group

  • Cell Pathology, Malmö
  • Clinical Chemistry, Malmö
  • Pathology, Malmö

ISBN/ISSN/Other

  • ISSN: 1879-0852