Generation of Transplantable Striatal Projection Neurons from Human ESCs.

Summary, in English

In this issue of Cell Stem Cell, Ma et al. (2012) report a differentiation protocol for generating striatal projection neurons from human embryonic stem cells with high efficiency. The cells survive transplantation, reconnect striatal circuitry, and restore motor function in a mouse model of striatal neurodegeneration that mimics the central pathohology of Huntington's disease.

• Author: Malin Parmar; Anders Björklund
• Department/s: Neurobiology; Developmental and Regenerative Neurobiology; StemTherapy: National Initiative on Stem Cells for Regenerative Therapy; MultiPark: Multidisciplinary research focused on Parkinson´s disease
• Publishing year: 2012
• Language: English
• Pages: 349-350
• Publication/Series: Cell Stem Cell
• Volume: 10
• Issue: 4
• Links: http://www.ncbi.nlm.nih.gov/pubmed/22482498?dopt=Abstract; http://dx.doi.org/10.1016/j.stem.2012.03.004
• Document type: Journal article
• Publisher: Cell Press
• Topic: Cell Biology
• Status: Published
• Research group: Neurobiology; Developmental and Regenerative Neurobiology
• ISBN/ISSN/Other: ISSN: 1934-5909