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The inflammatory mediator leukotriene D4 induces beta -catenin signaling and its association with anti-apoptotic Bcl-2 in intestinal epithelial cells.

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Author

Summary, in English

Increased levels of the inflammatory mediator leukotriene D-4 (LTD4) are present at sites of inflammatory bowel disease, and such areas also exhibit an increased risk for subsequent cancer development. It is known that LTD4 affects the expression of many proteins that influence survival and proliferation of intestinal epithelial cells. We demonstrate here that after LTD4 exposure, beta-catenin translocates to the nucleus where it signals activation of the TCF/LEF family of transcription factors. These events are mediated via a phosphatidylinositol 3-kinase-dependent phosphorylation of the inhibitory Ser-9 residue of glycogen synthase kinase 3 beta. We also show that in the presence of LTD4, free beta-catenin translocates to the mitochondria where it associates with the cell survival protein Bcl-2. We hypothesize that LTD4 may enhance cell survival via activation of beta-catenin signaling, in particular, by promoting the association of beta-catenin with Bcl-2 in the mitochondria. Similar to Wnt-1 signaling, LTD4 signals an increased level of free beta-catenin and elevated TCF/LEF promotor activity. This work in intestinal epithelial cells further lends credence to the idea that inflammatory signaling pathways are intrinsically linked with potential oncogenic signals involved in cell survival and apoptosis.

Publishing year

2006

Language

English

Pages

6776-6784

Publication/Series

Journal of Biological Chemistry

Volume

281

Issue

10

Document type

Journal article

Publisher

American Society for Biochemistry and Molecular Biology

Topic

  • Cancer and Oncology

Status

Published

Research group

  • Cell Pathology, Malmö
  • Experimental Pathology, Malmö

ISBN/ISSN/Other

  • ISSN: 1083-351X