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Chiral Separation of Amino Acids by Ligand-Exchange Electrochromatography Using Continuous Beds

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Author

  • Martin G. Schmid
  • Nina Grobuschek
  • Claudia Tuscher
  • Gerald Gübitz
  • Ákos Végvári
  • Egidijus Machtejevas
  • Audrius Maruska
  • Stellan Hjertén

Summary, in English

A chiral ligand-exchange phase for capillary electrochromatography based on continu-ous bed technology was developed. The chiral stationary phase is prepared by a one- step in situ copolymerization procedure using methacrylamide, piperazine diacryla- mide, vinylsulfonic acid and N-(2-hydroxy-3-allyloxypropyl)-L-4-hydroxyproline. These chiral continuous beds are inexpensive and easy to prepare. They also have several advantages over silica-based packed capillaries. Since the bed is covalently attached to the capillary wall, no frit is required. The applicability of this new approach to the chi- ral separation of underivatized amino acids is demonstrated.

Publishing year

2000

Language

English

Pages

3141-3144

Publication/Series

Electrophoresis

Volume

21

Issue

15

Document type

Journal article

Publisher

John Wiley & Sons Inc.

Topic

  • Medical Engineering

Keywords

  • Capillary electrochromatography
  • Enantiomer separation
  • Ligand-exchange
  • Continuous beds
  • Chiral beds
  • Monolithic phases

Status

Published

ISBN/ISSN/Other

  • ISSN: 0173-0835