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Increased Sensitivity to Broadly Neutralizing Antibodies of End-Stage Disease R5 HIV-1 Correlates with Evolution in Env Glycosylation and Charge.

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Author

  • Marie Borggren
  • Johanna Repits
  • Jasminka Sterjovski
  • Hannes Uchtenhagen
  • Melissa J Churchill
  • Anders Karlsson
  • Jan Albert
  • Adnane Achour
  • Paul R Gorry
  • Eva Maria Fenyö
  • Marianne Jansson
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Summary, in English

Induction of broadly neutralizing antibodies, such as the monoclonal antibodies IgGb12, 2F5 and 2G12, is the objective of most antibody-based HIV-1 vaccine undertakings. However, despite the relative conserved nature of epitopes targeted by these antibodies, mechanisms underlying the sensitivity of circulating HIV-1 variants to broadly neutralizing antibodies are not fully understood. Here we have studied sensitivity to broadly neutralizing antibodies of HIV-1 variants that emerge during disease progression in relation to molecular alterations in the viral envelope glycoproteins (Env), using a panel of primary R5 HIV-1 isolates sequentially obtained before and after AIDS onset.

Publishing year

2011

Language

English

Publication/Series

PLoS ONE

Volume

6

Issue

6

Document type

Journal article

Publisher

Public Library of Science (PLoS)

Topic

  • Microbiology in the medical area

Status

Published

Research group

  • HIV-1 and HIV-2 host interactions

ISBN/ISSN/Other

  • ISSN: 1932-6203