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Gerronemins A-F, cytotoxic biscatechols from a Gerronema species

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Author

Summary, in English

The gerronemins A-F (1-6) were isolated as the cytotoxic components of an extract of a Gerronema species detected in a screening for new cytotoxic metabolites from basidiomycetes. Their structures were elucidated by spectroscopic techniques, and they are composed of a C-12-C-16 alkane or alkene substituted at both ends by 2,3-dihydroxyphenyl groups. The gerronemins blocked the inducible expression of a hCOX-2 and iNOS promoter driven reporter gene with IC50-values of 1-5 mug/ml. In addition, cytotoxic activities were observed which were due the inhibition of cellular macromolecular syntheses.

Publishing year

2002

Language

English

Pages

643-648

Publication/Series

Phytochemistry

Volume

59

Issue

6

Document type

Journal article

Publisher

Elsevier

Topic

  • Organic Chemistry

Keywords

  • cytotoxic activity
  • biscatechols
  • Gerronema
  • gerronemins A-F

Status

Published

ISBN/ISSN/Other

  • ISSN: 0031-9422