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Enhanced and resumed GB virus C replication in HIV-1-infected individuals receiving HAART.

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Author

Summary, in English

In patients co-infected with HIV-1 and GB virus C (GBV-C), the disappearance of GBV-C RNA has been associated with accelerated disease progression. We studied longitudinal GBV-C viral titres in 28 HIV-1/GVB-C co-infected individuals receiving HAART. During HAART, median GBV-C RNA titres increased from 95 to 6000 copies/ml (P < 0.001). In patients interrupting HAART, GBV-C-RNA titres decreased as HIV replication resumed. These findings further support the theory that GBV-C replication could depend on the dynamics of HIV progression.

Department/s

Publishing year

2007

Language

English

Pages

1641-1643

Publication/Series

AIDS

Volume

21

Issue

12

Document type

Journal article

Publisher

Lippincott Williams & Wilkins

Topic

  • Infectious Medicine

Status

Published

Research group

  • Infectious Diseases Research Unit
  • Clinical Microbiology, Malmö

ISBN/ISSN/Other

  • ISSN: 1473-5571