Genome-wide association study identifies a common variant in RAD51B associated with male breast cancer risk
Author
Summary, in English
We conducted a genome-wide association study of male breast cancer comprising 823 cases and 2,795 controls of European ancestry, with validation in independent sample sets totaling 438 cases and 474 controls. A SNP in RAD51B at 14q24.1 was significantly associated with male breast cancer risk (P = 3.02 x 10(-13); odds ratio (OR) = 1.57). We also refine association at 16q12.1 to a SNP within TOX3 (P = 3.87 x 10(-15); OR = 1.50).
Department/s
- Breastcancer-genetics
- Breast and Ovarian Cancer Genomics
- EpiHealth: Epidemiology for Health
- BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
Publishing year
2012
Language
English
Pages
1182-1184
Publication/Series
Nature Genetics
Volume
44
Issue
11
Document type
Journal article
Publisher
Nature Publishing Group
Topic
- Cancer and Oncology
Status
Published
Research group
- Breast and Ovarian Cancer Genomics
ISBN/ISSN/Other
- ISSN: 1546-1718