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Cyclin e overexpression reduces infiltrative growth in breast cancer - Yet another link between proliferation control and tumor invasion

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Author

  • Pontus Berglund
  • Göran Landberg

Summary, in English

Overexpression of cyclin E is strongly linked to an aggressive phenotype and poor prognosis in breast cancer. Unexpectedly, it has been shown that cyclin E overexpression decreases mobility and invasiveness of breast cancer cells. In fact, in a study of 985 breast cancers, cyclin E correlated with less infiltrative growth. This suggests a novel function for cyclin E in breast cancer tumorigenesis and a mutual control of proliferation and invasive behavior.

Department/s

Publishing year

2006

Language

English

Pages

606-609

Publication/Series

Cell Cycle

Volume

5

Issue

6

Document type

Journal article

Publisher

Landes Bioscience

Topic

  • Cell Biology

Keywords

  • medullary breast
  • proliferation
  • invasion
  • breast cancer
  • cyclin E
  • microarray
  • cancer

Status

Published

Research group

  • Pathology, Malmö

ISBN/ISSN/Other

  • ISSN: 1551-4005