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Detrusor contraction - Focus on muscarinic receptors

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Author

Summary, in English

Stimulation of muscarinic receptors is a main mechanism for contractile activation of the detrusor from both animals and humans. Muscarinic receptors are coupled to G-proteins, but the signal transduction systems may vary. In general, M-1 , M-3 and M-5 receptors are considered to couple preferentially to G(q/11) , activating phosphoinositide hydrolysis, in turn leading to mobilization of intracellular calcium through inositol trisphosphate generation. M-2 and M-4 receptors couple to pertussis toxin-sensitive G(i/o) , resulting in inhibition of adenylyl cyclase activity. However, in the detrusor smooth muscle, other signalling pathways may be involved. Recent investigations revealed that a main pathway for muscarinic receptor activation of the detrusor may be calcium influx via L-type calcium channels, and increased sensitivity to calcium of the contractile machinery via inhibition of myosin light chain phosphatase through activation of Rho-kinase. The importance of these findings for treatment of voiding dysfunction remains to be established.

Publishing year

2004

Language

English

Pages

54-57

Publication/Series

Scandinavian Journal of Urology and Nephrology

Volume

38

Issue

Suppl 215

Document type

Journal article review

Publisher

Taylor & Francis

Topic

  • Medicinal Chemistry
  • Pharmacology and Toxicology

Keywords

  • sensitivity
  • calcium
  • contractile proteins
  • bladder
  • signal transduction
  • acetylcholine

Status

Published

ISBN/ISSN/Other

  • ISSN: 0036-5599