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Transcriptional adaptation of neuroblastoma cells to hypoxia.

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Author

Summary, in English

Low oxygen pressure (hypoxia) is a physiological condition that has been linked to tumor progression and increased malignancy in several cancer forms. Cells of the childhood neoplasm neuroblastoma respond to hypoxia by attaining a lower grade of differentiation, which clinically is associated with poor prognosis. Furthermore, expression of the hypoxia inducible factor-2alpha correlates to poor outcome in neuroblastoma patients. In this report we have by microarray analysis studied transcriptional changes in seven neuroblastoma cell lines subjected to long term hypoxia. We find the gene regulatory response to be highly dependent on cell line background, however, a set of genes was coherently regulated by hypoxia and these genes are correlated to known hypoxia-induced transcriptional profiles.

Publishing year

2008

Language

English

Pages

1054-1060

Publication/Series

Biochemical and Biophysical Research Communications

Volume

366

Issue

4

Document type

Journal article

Publisher

Elsevier

Topic

  • Biological Sciences

Keywords

  • Hypoxia-Inducible Factor 1: metabolism
  • Neuroblastoma: pathology
  • Neuroblastoma: genetics

Status

Published

ISBN/ISSN/Other

  • ISSN: 1090-2104