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The structure of the semenogelin gene locus--nucleotide sequence of the intergenic and the flanking DNA

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Author

Summary, in English

The sequence of 15.7 kb from the human semenogelin gene locus has been determined. Together with previously published sequences, this gives the structure of a 28-kb region encompassing the two semenogelin genes. The two transcription units are separated by 11616 bp intergenic DNA comprising more than 40% repetitive DNA sequences, predominantly located to a 4-kb block of L1 and Alu repeats. Two more blocks of L1 sequences are present in the DNA flanking the genes, so that approximately 20% of the completed sequence consists of long interspersed repeated sequences, so called LINES. A comparison of the SgI gene and the SgII gene suggests that they evolved by the duplication of an approximately 8 kb DNA segment about 61 million years ago, probably by a mechanism involving recombination between L1 elements.

Publishing year

1996

Language

English

Pages

70-466

Publication/Series

Eur J Biochem

Volume

235

Issue

3

Document type

Journal article

Publisher

Wiley-Blackwell

Topic

  • Medicinal Chemistry

Keywords

  • Repetitive Sequences
  • Multigene Family
  • Molecular Sequence Data
  • Humans
  • Gonadal Steroid Hormones/*genetics
  • Dna
  • Molecular
  • Cloning
  • Base Sequence
  • Chromosome Mapping
  • Nucleic Acid
  • Non-U.S. Gov't
  • Research Support
  • *Seminal Vesicle Secretory Proteins
  • Sequence Homology

Status

Published

Research group

  • Clinical Chemistry, Malmö