Early diagnostic value of Bcl-3 localization in colorectal cancer.

Summary, in English

B-cell leukemia 3 (Bcl-3) is a member of the inhibitor of κB family, which regulates a wide range of biological processes by functioning as a transcriptional activator or as a repressor of target genes. Elevated expression, sustained nuclear accumulation, and uncontrolled activation of Bcl-3 causes increased cellular proliferation or survival, dependent on the tissue and type of stimuli.

• Author: Karunakar Saamarthy; Sofie Björner; Martin Johansson; Göran Landberg; Ramin Massoumi; Karin Jirström; Katarzyna Masoumi
• Department/s: Division of Translational Cancer Research; Pathology, Malmö; Clinical pathology, Malmö; BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation; Tumor microenvironment
• Publishing year: 2015
• Language: English
• Publication/Series: BMC Cancer
• Volume: 15
• Issue: 1
• Full text: - 3 MB; Download statistics
• Links: http://www.ncbi.nlm.nih.gov/pubmed/25929479?dopt=Abstract; http://dx.doi.org/10.1186/s12885-015-1342-6
• Document type: Journal article
• Publisher: BioMed Central (BMC)
• Topic: Cancer and Oncology
• Status: Published
• Research group: Pathology, Malmö; Clinical pathology, Malmö
• ISBN/ISSN/Other: ISSN: 1471-2407