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Base-catalyzed intramolecular condensation of tokinolide B.

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Author

  • B Quiroz-García
  • L Hernández
  • R A Toscano
  • Olov Sterner
  • G Delgado

Summary, in English

The novel pentacyclic compound cyclotokinolide B was obtained from the natural phthalide tokinolide B under basic conditions, via the chemoselective -enol lactone opening followed by a Michael addition of the generated carbanion to the enone and subsequent equilibration. This result confirms that some dimeric phthalides undergo intramolecular cyclizations in basic media.

Publishing year

2003

Language

English

Pages

2509-2512

Publication/Series

Tetrahedron Letters

Volume

44

Issue

12

Document type

Journal article

Publisher

Elsevier

Topic

  • Organic Chemistry

Status

Published

ISBN/ISSN/Other

  • ISSN: 0040-4039